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(U) 1.4 (n) -2.9 (i) -1.5 (v) 1 (e) -2.9 (r) -4.3 (s) -5.1 (i) -1.5 (t) 6.5 () 3.1 (\040) ] TJ 0.001 Tc 0.23 Tw -19.713 -1.725 Td [ (de\040N) 4.4 (ant) 3.6 (e) 6.1 (s) -2 (\054) 3.6 (\040N) -1.5 (ant) 3.6 (e) 6.1 (s) -2 (\054) 3.5 (\040F) 1.2 (r) 4.7 (an) 6.1 (c) -2 (e\073) 3.6 (\040) ] TJ 0 Tc 0 Tw 6.48 0 0 6.48 205.32 640.5 Tm (3) Tj 0.001 Tc 0.23 Tw 10.02 0 0 10.02 208.92 637.02 Tm [ (U) -1.5 (ni) 1.4 (v) 4 (e) 6.1 (r) -1.3 (s) -2 (i) 1.5 (t) 9.5 (\040de\040R) 4.5 (enn) 6.1 (es) 3.9 (\0401\054) 3.5 (\040U) -1.6 (M) 1.7 (R) 4.4 (629) 6.1 (0\040C) 4.5 (N) -1.6 (R) -1.5 (S) 3.3 (\054) 3.6 (\040I) 3.6 (ns) 4 (t) 3.5 (i) 1.5 (t) 3.6 (ut) 3.5 (\040de\040G) 0.6 (n) 6.1 (t) 3.6 (i) 1.4 (que\040e) 6.1 (t) 9.6 (\040) ] TJ -0.003 Tw -13.772 -1.719 Td [ (D) -1.5 (v) 4 (el) 1.4 (o) 6.1 (ppem) 7.7 (ent) 3.6 (\040) 0.5 (de\040) 0.5 (R) -1.5 (e) 6.1 (nne) 6.1 (s) -2 (\054) 3.6 (\040) 0.6 (R) -1.6 (en) 6.1 (ne) 6.1 (s) -2 (\054) 3.6 (\040) 0.5 (F) 1.2 (r) 4.7 (anc) 4 (e) ] TJ 0 Tc 0 Tw 19.749 0 Td (\040) Tj EMC /P << /MCID 6 >> BDC 0.001 Tc -0.009 Tw -19.748 -1.725 Td [ (\052) 0.8 (F) 1.2 (or) -1.3 (\040) 0.6 (c) -2 (or) 4.7 (r) -1.4 (e) 6.1 (s) -1.9 (po) 6.1 (nden) 6.2 (c) -2 (e\072) 3.6 (\040) ] TJ EMC /Link << /MCID 7 >> BDC 0 0 1 rg -0.001 Tc 0.001 Tw 9.88 0 Td [ (g) -1.9 (i) -0.6 (ll) -0.6 (e) 4.1 (s) 2 (\056) 1.5 (s) -4 (a) -1.9 (lb) -1.9 (e) 4.1 (r) -3.4 (t) 1.6 (\100) 2 (u) -1.9 (n) -1.9 (iv) ] TJ 0 Tc 0 Tw 8.383 0 Td (\055) Tj 0.001 Tc -0.001 Tw 0.335 0 Td [ (r) -1.3 (e) 6.1 (nne) 6.1 (s) -1.9 (1\056) 3.5 (f) 3.6 (r) ] TJ EMC ET /Span << /MCID 8 >> BDC BT 0 g 0 Tc 0 Tw 10.02 0 0 10.02 302.34 602.52 Tm (\040) Tj 0.491 0 Td (\040) Tj ET 0 0 1 rg 169.92 600.72 132.42 0.72 re f EMC BT /P << /MCID 9 >> BDC 0 g /TT2 1 Tf 10.02 0 0 10.02 70.92 585.24 Tm (\040) Tj EMC ET /P << /MCID 10 >> BDC 1 g 124.92 565.8 399.48 11.76 re f* BT 0 g 0.002 Tc -0.002 Tw 10.02 0 0 10.02 70.92 568.02 Tm [ (\133A) -0.6 (b) 8.2 (s) 1.1 (tr) 7.8 (a) 1.1 (c) 1.1 (t) 5.7 (\135\040) ] TJ /TT1 1 Tf 0.001 Tc 0.392 Tw 5.389 0 Td [ (T) 7.2 (hi) 1.5 (s) -2 (\040pr) 4.6 (ot) 3.6 (oc) 4 (ol) 7.5 (\040i) 1.5 (s) -2 (\040des) -2 (i) 1.5 (g) 6.1 (ned) 6.1 (\040t) 3.5 (o\040obt) 3.6 (ai) 1.5 (n\040bas) -2 (e) ] TJ 0 Tc 0 Tw 19.958 0 Td (\055) Tj 0.001 Tc 0.392 Tw 0.335 0 Td [ (r) 4.7 (es) 4 (ol) 1.5 (ut) 3.5 (i) 1.5 (o) 6.1 (n\040i) 1.4 (nf) 3.6 (or) -1.3 (m) 1.7 (at) 3.5 (i) 1.5 (o) 6.1 (n\040on\040t) 3.5 (he\040l) 1.5 (ev) 4 (el) 1.4 (\040of) 3.6 (\0405) ] TJ 0 Tc 0 Tw (\055) Tj ET 1 g 70.92 548.58 453.48 11.52 re f* BT 0 g 0.001 Tc 0.098 Tw 10.02 0 0 10.02 70.92 550.8 Tm [ (hy) 4 (dr) -1.3 (ox) 3.9 (y) 4 (m) 1.7 (et) 3.6 (h) 6.1 (y) 4 (l) 1.5 (c) -2 (y) 4 (t) 3.5 (os) -1.9 (i) 1.4 (ne\040) 5.8 (\050) -1.3 (5) 6.1 (hm) 1.7 (C) 4.4 (\051) -1.3 (\040i) 1.4 (n\040) 5.8 (C) -1.5 (p) 6.1 (G) 6.5 (s) -2 (\040) 5.8 (w) -1.6 (i) 1.5 (t) 3.6 (hout) 3.6 (\040t) 3.6 (he) 6.1 (\040need) 6.1 (\040f) ] TJ 26.431 0 Td [ (or) -1.3 (\040) 5.8 (bi) 1.4 (s) 4 (ul) 1.4 (f) 3.6 (i) 1.4 (t) 3.6 (e\040m) 1.6 (odi) 1.4 (f) 3.6 (i) 1.4 (c) 4 (at) 3.5 (i) 1.5 (on\056) 3.6 (\040I) 3.6 (t) 3.6 (\040r) -1.3 (el) 1.5 (i) 1.4 (e) 6.1 (s) -2 (\040) ] TJ -0.001 Tw (on) Tj 0 Tc 0 Tw 15.808 0 Td (\040) Tj 0.377 0 Td (\050) Tj 0.335 0 Td (i) Tj -0.005 Tc 0.104 Tw 0.216 0 Td [ (\051) -7.3 (\040t) -2.4 (he\040) ] TJ ET 1 g 70.92 531.3 453.48 11.52 re f* BT 0 g 0.001 Tc 0.075 Tw 10.02 0 0 10.02 70.92 533.52 Tm [ (c) -2 (apt) 3.6 (u) 6.1 (r) -1.3 (e\040) 0.7 (of) 3.6 (\040) 0.7 (hy) 10 (dr) -1.3 (ox) 4 (y) 4 (m) 1.7 (et) 3.6 (hy) 4 (l) 1.5 (a) 6.1 (t) 3.5 (ed\040) 0.7 (s) -2 (e) 6.1 (quen) 6.1 (c) -2 (e) 6.1 (s) -2 (\040) 0.7 (by) 4 (\040) 0.7 (a\040) 0.7 (p) 6.1 (r) -1.3 (o) 6.1 (c) -2 (e) 6.1 (dur) -1.4 (e\040) 6.7 (k) -2 (n) 6.1 (ow) 4.4 (n\040) 6.7 (as) -2 (\040) 0.7 (\221) 7.4 (s) -2 (el) 1.4 (e) 6.1 (c) -2 (t) 3.6 (i) 1.5 (v) 4 (e\040) 0.7 (c) -2 (hem) ] TJ -0.007 Tc 0.007 Tw 37.497 0 Td [ (i) -0.6 (c) -10 (a) -7.8 (l) -6.6 (\040) ] TJ 0.001 Tc -0.001 Tw 1.85 0 Td [ (l) 7.5 (ab) 6.1 (el) 1.5 (i) 1.4 (ng) ] TJ -0.005 Tc 0.081 Tw [ (\222) 31.4 (\040) 0.7 (\050) -1.4 (s) -7.9 (ee\040) ] TJ 0.001 Tc -0.001 Tw -39.347 -1.719 Td [ (S) 3.3 (z) -1.9 (ul) 1.4 (w) 4.5 (ac) 4 (h\040) ] TJ /TT3 1 Tf 4.737 0 Td (et) Tj /TT1 1 Tf 0 Tc 0 Tw 0.832 0 Td (\040) Tj /TT3 1 Tf 0.001 Tc -0.001 Tw 0.467 0 Td (al) Tj /TT1 1 Tf 0.182 Tw 0.778 0 Td [ (\056) 3.6 (\054) 3.5 (\0402012\051) -1.3 (\040an) 6.1 (d\040\050) ] TJ -0.001 Tc 0.001 Tw 6.497 0 Td [ (i) -0.6 (i) ] TJ 0.001 Tc 0.182 Tw [ (\051) -1.4 (\040t) 3.5 (he\040di) 1.4 (ges) -1.9 (t) 3.5 (i) 1.5 (on\040of) 3.5 (\040t) 3.5 (he\040c) -2 (apt) 3.6 (ur) -1.3 (e) 6.1 (d\040D) 4.4 (N) -1.5 (A) 57.2 (\040by) 3.9 (\040ex) 4 (onuc) -2 (l) 1.4 (ea) 6.1 (s) -2 (e) 6.1 (s) -2 (\056) 3.6 (\040A) 3.3 (f) 3.6 (t) 3.5 (e) -5.8 (r) -1.3 (\040I) 3.6 (l) 1.4 (l) 1.4 (um) 1.7 (i) 1.4 (na) 6.1 (\040) ] TJ -0.033 Tw -13.311 -1.719 Td [ (s) -2 (eq) 6.1 (uen) 6.1 (c) -2 (i) 1.5 (ng\040) 0.5 (o) 6.1 (f) 3.6 (\040t) 3.6 (he\040) 0.5 (di) 1.4 (ges) -2 (t) 3.5 (ed) 6.2 (\040) 0.5 (D) -1.6 (N) -1.5 (A) 57.2 (\040) 0.5 (f) 3.5 (r) -1.3 (agm) 1.6 (e) 6.1 (nt) 3.5 (s) -2 (\054) 3.6 (\040) 0.5 (an\040) ] TJ /TT3 1 Tf 20.719 0 Td [ (ad\040) 0.5 (ho) 6.1 (c) ] TJ /TT1 1 Tf 0 Tc 0 Tw 2.97 0 Td (\040) Tj 0.001 Tc -0.033 Tw 0.246 0 Td [ (bi) 1.5 (oi) 1.4 (nf) 3.5 (or) 4.7 (m) 1.7 (at) 3.6 (i) 7.4 (c) -2 (\040) 0.5 (pi) 1.5 (pel) 1.5 (i) 1.4 (n) 6.1 (e\040) 0.5 (ex) 4 (t) 3.5 (r) -1.3 (ac) -2 (t) 3.6 (s) -2 (\040) 0.5 (t) 3.5 (he\040) 0.5 (i) 1.4 (nf) 3.5 (or) 4.7 (m) 1.7 (at) 3.6 (i) 1.4 (on\040) 0.5 (f) 3.6 (or) 4.7 (\040) ] TJ -0.003 Tw -23.934 -1.725 Td [ (f) 3.6 (ur) -1.3 (t) 3.5 (her) -1.4 (\040) 0.6 (d) 6.1 (ow) 4.5 (ns) 4 (t) 3.5 (r) -1.3 (eam) 1.6 (\040) 0.6 (an) 6.1 (al) 1.5 (y) 4 (s) -2 (i) 7.4 (s) -2 (\056) ] TJ 0 Tc 0 Tw 12.76 0 Td (\040) Tj ET EMC /P << /MCID 11 >> BDC 1 g 70.92 462.36 422.94 11.76 re f* BT 0 g /TT2 1 Tf 10.02 0 0 10.02 70.92 464.58 Tm [ (K) -2.6 (e) -6.8 (y) 29 (w) -24.4 (o) 6.2 (rds) 5.1 (\072) -2.3 (\040) ] TJ /TT1 1 Tf 5.383 0 Td (5) Tj 0.551 0 Td (\055) Tj 0.001 Tc -0.003 Tw 0.335 0 Td [ (H) -1.5 (y) 4 (d) 6.1 (r) -1.3 (ox) 4 (y) 4 (m) 1.6 (et) 3.5 (hy) 4 (l) 1.5 (c) -2 (y) 4 (t) 3.6 (os) -2 (i) 1.4 (n) 6.1 (e\054) 3.5 (\040) 0.6 (S) 3.3 (el) 1.5 (ec) -2 (t) 3.6 (i) 1.4 (v) 4 (e\040) 0.6 (c) -2 (h) 6.1 (e) ] TJ -0.001 Tc 0.001 Tw 16.748 0 Td [ (mi) -0.6 (c) -4 (a) -1.9 (l) -0.6 (\040) ] TJ 2.611 0 Td [ (l) -0.6 (a) -1.9 (b) 4.1 (e) -1.9 (li) -0.6 (n) -1.9 (g) ] TJ 0.001 Tc -0.003 Tw 3.437 0 Td [ (\054) 3.6 (\040) 0.5 (E) 3.3 (x) 4.1 (onuc) -2 (l) 1.5 (ea) 6.1 (s) 4 (e\040) 0.6 (di) 1.5 (ge) 6.1 (s) -2 (t) 3.5 (i) 1.5 (on\054) ] TJ 0 Tc 0 Tw 10.82 0 Td (\040) Tj -0.004 Tc 0.004 Tw 0.275 0 Td [ (C) -0.6 (p) -4.9 (G) ] TJ /TT2 1 Tf 0 Tc 0 Tw 2.048 0 Td (\040) Tj ET EMC BT /P << /MCID 12 >> BDC 10.02 0 0 10.02 70.92 447.24 Tm (\040) Tj EMC ET /P << /MCID 13 >> BDC 1 g 135.96 427.86 388.44 11.76 re f* BT 0 g 10.02 0 0 10.02 70.92 430.08 Tm [ (\133) -2.3 (B) -2.6 (a) 5.1 (c) -0.9 (k) -0.8 (gr) 5.7 (oun) 6.2 (d\135) ] TJ 6.491 0 Td (\040) Tj /TT1 1 Tf 0.001 Tc 0.134 Tw 0.413 0 Td [ (T) 1.2 (he\040m) 1.7 (et) 3.6 (h) 6.1 (y) 4 (l) 1.4 (at) 3.6 (i) 1.4 (on\040of) 3.6 (\040c) -1.9 (y) 4 (t) -2.5 (os) -1.9 (i) 1.4 (n) 6.1 (e\040i) 1.4 (n\040genom) 1.6 (i) 1.5 (c) -2 (\040D) 4.5 (N) -1.6 (A) 57.3 (\040c) -2 (a) 6.1 (n\040) ] TJ [ (be\040r) -1.4 (ead) ] TJ 0 Tc 0 Tw (\040) Tj 0.001 Tc 0.134 Tw 26.808 0 Td [ (by) 4 (\040pr) -1.3 (ot) 3.5 (ei) 1.4 (ns) -2 (\040an) 6.1 (d) 6.1 (\040) ] TJ -0.001 Tc 0.136 Tw [ (i) -0.6 (s) -4 (\040ma) -1.9 (i) -0.6 (n) -1.9 (ly) -4 (\040) ] TJ ET 1 g 70.92 410.58 453.48 11.52 re f* BT 0 g 0.001 Tc -0.001 Tw 10.02 0 0 10.02 70.92 412.8 Tm [ (t) 3.6 (r) -1.4 (ans) -2 (l) 7.4 (at) 3.5 (ed) ] TJ 0 Tc 0 Tw (\040) Tj 0.001 Tc 0.033 Tw 4.701 0 Td [ (i) 1.5 (nt) 3.5 (o\040) 0.7 (gene\040) 0.6 (s) -2 (i) 1.5 (l) 1.4 (e) 6.1 (nc) 4 (i) 1.5 (ng\056) 3.6 (\040) 0.6 (M) 1.7 (os) -2 (t) 3.6 (\040) 0.6 (C) -1.5 (p) 6.1 (G) 0.6 (\040) 0.6 (di) 1.5 (nuc) -2 (l) 7.5 (eot) 3.6 (i) 1.4 (d) 6.1 (es) -1.9 (\040) 0.6 (i) 1.4 (n\040) 0.7 (t) 3.6 (he\040) 0.6 (gen) 6.1 (om) 1.7 (e\040) 0.6 (ar) -1.3 (e\040) 0.7 (m) 1.6 (et) 9.5 (hy) 4 (l) 1.5 (at) 3.6 (ed\054) 3.6 (\040) 0.6 (i) 1.4 (nc) -2 (l) 1.4 (u) 6.1 (di) 1.4 (ng\040) 0.6 (t) 3.6 (hos) 4 (e) 6.1 (\040) ] TJ ET 1 g 70.92 393.36 453.48 11.52 re f* BT 0 g 0.08 Tw 10.02 0 0 10.02 70.92 395.58 Tm [ (l) 1.5 (oc) -2 (at) 3.6 (e) 6.1 (d\040i) 1.5 (n\040ge) 6.1 (ne\040r) -1.3 (e) 6.1 (gul) 1.5 (at) ] TJ 10.353 0 Td [ (o) 6.1 (r) -1.3 (y) 4 (\040r) -1.3 (egi) 1.5 (o) 6.1 (ns) -2 (\040) 5.7 (s) -1.9 (u) 6.1 (c) -2 (h) 6.1 (\040as) -2 (\040en) 6.1 (han) 6.1 (c) -1.9 (e) 6.1 (r) 4.6 (s) -1.9 (\056) 3.5 (\040H) -1.5 (o) 6.1 (w) -1.5 (ev) 4 (e) 6.1 (r) 52.6 (\054) 3.5 (\040w) -1.5 (he) 6.1 (n\040r) -1.3 (e) 6.1 (qui) 1.5 (r) 4.6 (e) 6.1 (d\054) 3.5 (\040) ] TJ 0.075 Tw [ (t) 3.6 (hes) -2 (e\040) 0.7 (C) -1.6 (pG) 6.5 (s) ] TJ 0 Tc 0 Tw 31.479 0 Td (\040) Tj -0.005 Tc 0.081 Tw 0.359 0 Td [ (c) -2 (a) -5.9 (n) -5.9 (\040) 0.7 (be\040) ] TJ ET 1 g 70.92 376.08 453.48 11.52 re f* BT 0 g 0.001 Tc 0.051 Tw 10.02 0 0 10.02 70.92 378.3 Tm [ (dem) 1.7 (et) 3.6 (hy) 4 (l) 1.5 (at) 3.5 (ed) 6.1 (\040) 0.6 (t) 3.6 (hr) -1.3 (ough) ] TJ 0 Tc 0 Tw (\040) Tj 0.001 Tc -0.001 Tw 10.048 0 Td (ox) Tj 0 Tc 0 Tw 1.054 0 Td (i) Tj 0.001 Tc -0.001 Tw 0.222 0 Td [ (d) 6.1 (at) 3.6 (i) 1.4 (on) ] TJ 0 Tc 0 Tw (\040) Tj 0.001 Tc 0.051 Tw 3.048 0 Td [ (of) 3.6 (\040) 0.7 (t) 3.5 (he\040) -5.3 (m) 1.7 (et) 3.6 (h) ] TJ [ (y) 4 (l) 1.4 (\040) 0.7 (gr) -1.3 (oup) 6.1 (\040) 0.7 (by) 4 (\040) 12.7 (T) 109 (en\040) 0.7 (E) 3.3 (l) 1.5 (ev) -2 (en\040) 12.7 (T) 37.1 (r) -1.3 (an) 6.1 (s) -2 (l) 1.5 (o) 6.1 (c) -2 (at) 9.5 (i) 1.4 (on\040) 0.7 (\050) -1.4 (T) 1.2 (E) 3.4 (T) 1.2 (\051) -1.3 (\040) 0.7 (en) 6.1 (z) -2 (y) 4 (m) 1.7 (es) -2 (\040) 6.7 (a) 6.1 (n) 6.1 (d) 6.1 (\040) ] TJ ET 1 g 70.92 358.86 453.48 11.52 re f* BT 0 g 0.039 Tw 10.02 0 0 10.02 70.92 361.08 Tm [ (r) -1.3 (epl) 1.5 (a) 6.1 (c) -2 (e) 6.1 (m) 1.7 (ent) 3.6 (\040) 0.6 (by) 4 (\040) 0.7 (unm) 1.7 (et) 3.6 (hy) 4 (l) 1.5 (at) 3.5 (ed\040) 0.6 (c) -2 (y) 4 (t) 3.6 (os) -2 (i) 1.5 (ne) 6.1 (s) 4 (\040) 0.6 (by) 4 (\040) -5.4 (t) 3.6 (he\040) 0.7 (bas) -2 (e\040) 0.7 (ex) 4 (c) -2 (i) 1.5 (s) -2 (i) 7.4 (on\040) 0.6 (r) -1.3 (ep) 6.1 (a) 6.1 (i) 1.5 (r) -1.4 (\040) 0.7 (s) -2 (y) 4 (s) -2 (t) 3.6 (em) 1.7 (\056) 3.5 (\040) 0.7 (5) ] TJ 0 Tc 0 Tw (\055) Tj 35 0 Td (H) Tj -0.003 Tc 0.003 Tw 0.725 0 Td [ (yd) -3.9 (r) -5.3 (o) -3.9 (xym) -2.3 (e) -3.9 (th) 2.1 (yl) -2.5 (c) -6 (yto) -3.9 (s) -6 (i) -2.5 (n) 2.1 (e) 2 (\040) ] TJ ET 1 g 70.92 341.58 453.48 11.52 re f* BT 0 g 0.001 Tc 0.164 Tw 10.02 0 0 10.02 70.92 343.8 Tm [ (\050) -1.3 (5hm) 7.7 (C) -1.6 (\051) -1.3 (\040i) 1.5 (s) -2 (\040t) 3.5 (h) 6.1 (e\040f) 3.6 (i) 1.5 (r) -1.4 (s) -2 (t) 3.6 (\040ox) 4 (i) 1.5 (dat) 3.6 (i) 1.4 (v) 4 (e\040der) -1.3 (i) 1.4 (v) 4 (at) 3.6 (i) 1.4 (v) 4 (e\040of) 3.5 (\0405) ] TJ 0 Tc 0 Tw (\055) Tj 0.001 Tc 0.164 Tw 20.096 0 Td [ (m) 1.7 (et) 3.5 (hy) 4 (l) 1.4 (c) -2 (y) 4 (t) 3.6 (os) -2 (i) 1.5 (ne\054) 3.6 (\040and\040m) 1.7 (appi) 1.4 (n) 6.1 (g\040t) 3.6 (hi) 1.5 (s) 4 (\040m) 1.6 (odi) 1.4 (f) 3.6 (i) 1.4 (ed\040bas) -2 (e\040i) 1.5 (n\040t) 3.6 (he\040) ] TJ ET 1 g 70.92 324.36 453.48 11.52 re f* BT 0 g 0.242 Tw 10.02 0 0 10.02 70.92 326.58 Tm [ (genom) 7.6 (e\040pr) -1.3 (ov) 10 (i) 1.5 (des) -2 (\040) -5.9 (i) 7.4 (nf) 3.5 (or) -1.3 (m) 7.7 (at) 3.5 (i) 1.5 (on\040on\040) -5.9 (t) 3.6 (he\040r) 4.6 (egi) 1.4 (on) 6.1 (s) -1.9 (\040unde) 6.1 (r) 4.6 (goi) 1.4 (ng\040ac) -2 (t) 3.5 (i) 1.5 (v) 4 (e\040dem) 1.7 (et) 3.5 (hy) 4 (l) 1.4 (at) 3.6 (i) 1.4 (o) 6.1 (n\056) 3.5 (\040) -5.9 (A) 3.3 (l) 1.5 (t) 3.5 (hough\040s) -2 (el) 1.5 (e) 6.1 (c) -2 (t) 3.6 (i) 1.4 (v) 4 (e) 6.1 (\040) ] TJ ET 1 g 70.92 307.08 453.48 11.52 re f* BT 0 g -0.001 Tw 10.02 0 0 10.02 70.92 309.3 Tm [ (c) -2 (hem) 1.7 (i) 7.5 (c) ] TJ -0.001 Tc 0.001 Tw 3.168 0 Td [ (a) -1.9 (l) -0.6 (\040) ] TJ 1.006 0 Td [ (l) -0.6 (a) 4.1 (b) -1.9 (e) 4.1 (li) -0.6 (n) -1.9 (g) ] TJ 0 Tc 0 Tw 3.437 0 Td (\040) Tj 0.228 0 Td (\050) Tj 0.001 Tc -0.051 Tw 0.335 0 Td [ (S) 3.3 (C) 4.5 (L\051) -1.3 (\040al) 1.4 (l) 7.4 (ow) 4.4 (s) -2 (\040) ] TJ -0.003 Tc 0.003 Tw 5.503 0 Td [ (ve) -3.9 (r) -5.3 (y) ] TJ 0 Tc 0 Tw (\040) Tj 0.001 Tc -0.051 Tw 2.114 0 Td [ (s) -2 (p) 6.1 (e) 6.1 (c) -1.9 (i) 1.4 (f) 3.6 (i) 1.4 (c) -2 (\040) 0.5 (det) 3.6 (e) 6.1 (c) -2 (t) 3.6 (i) 1.4 (on) 6.1 (\040) 0.5 (of) 3.6 (\040) 0.5 (5hm) 1.7 (C) -1.6 (\054) 3.6 (\040t) 3.6 (he\040) 6.5 (r) -1.3 (es) 4 (ol) 1.5 (ut) 3.6 (i) 1.4 (on\040) 0.5 (of) 3.6 (\040) 0.5 (t) 9.5 (hi) 1.5 (s) -2 (\040) 0.5 (t) 3.5 (ec) 4 (hni) 1.4 (q) 6.1 (ue\040) 6.4 (i) 1.5 (s) -2 (\040) 0.5 (l) 1.4 (i) 1.5 (m) 1.6 (i) 1.5 (t) 3.5 (ed\040) ] TJ ET 1 g 70.92 289.86 453.48 11.52 re f* BT 0 g 0.045 Tw 10.02 0 0 10.02 70.92 292.08 Tm [ (by) 4 (\040) 0.7 (t) 3.5 (he\040) 0.6 (s) -2 (i) 7.5 (z) -2 (e\040) 6.7 (of) 3.5 (\040) 0.7 (t) 3.5 (he\040) 0.6 (D) 4.5 (N) -1.6 (A) 57.3 (\040) 0.6 (f) 3.6 (r) 4.6 (ag) 6.1 (m) 1.6 (ent) 3.5 (s) -1.9 (\054) 3.5 (\040) 0.7 (e) 6.1 (s) -2 (p) 6.1 (ec) 4 (i) 1.5 (al) 1.4 (l) 1.5 (y) 4 (\040) 0.6 (w) -1.5 (he) 6.1 (n\040) 0.7 (s) 4 (e) 6.1 (v) 4 (er) -1.3 (al) 1.5 (\040) 6.6 (C) -1.5 (pG) 6.5 (s) -1.9 (\040) 0.6 (a) 6.1 (r) -1.3 (e\040) 0.7 (p) 6.1 (r) -1.3 (e) 6.1 (s) -2 (ent) 3.6 (\040) 0.6 (i) 1.5 (n) 6.1 (\040) 6.6 (t) 3.6 (he\040) 0.7 (c) -2 (a) 6.1 (pt) 3.6 (ur) 4.7 (ed\040) 6.7 (D) -1.6 (N) -1.5 (A) 3.3 (\056) 3.5 (\040) ] TJ -0.005 Tc 0.005 Tw 44.431 0 Td [ (I) -2.4 (n\040) ] TJ ET 1 g 70.92 272.58 453.48 11.52 re f* BT 0 g 0.001 Tc 0.098 Tw 10.02 0 0 10.02 70.92 274.8 Tm [ (or) -1.3 (de) 6.1 (r) -1.3 (\040t) 3.5 (o) ] TJ 0 Tc 0 Tw (\040) Tj 0.001 Tc 0.098 Tw 3.922 0 Td [ (i) 1.5 (m) 1.6 (pr) 4.7 (ov) 4 (e\040r) -1.3 (es) 4 (ol) 1.5 (ut) 3.6 (i) 1.4 (o) 6.1 (n\054) 3.5 (\040w) -1.6 (e\040hav) 4 (e\040i) 1.4 (nt) 3.6 (r) -1.3 (odu) 6.1 (c) -2 (e) 6.1 (d\040a\040di) 1.5 (ge) 6.1 (s) -2 (t) 3.6 (i) 1.4 (on\040s) -1.9 (t) 3.5 (e) 6.1 (p\040us) -2 (i) 1.5 (ng\040ex) 4 (o) 6.1 (n) 6.1 (uc) -2 (l) 1.4 (e) 6.1 (as) 4 (es) -2 (\040) ] TJ [ (w) 4.4 (hi) 7.5 (c) -2 (h\040t) 3.5 (r) -1.3 (i) 1.5 (m) 1.6 (\040t) 3.6 (he) 6.1 (\040) ] TJ ET 1 g 70.92 255.36 453.48 11.52 re f* BT 0 g 0.194 Tw 10.02 0 0 10.02 70.92 257.58 Tm [ (D) -1.5 (N) -1.6 (A) 57.2 (\040m) 1.7 (ol) 1.4 (e) 6.1 (c) -1.9 (ul) 7.4 (e\040up\040t) 3.5 (o\040) ] TJ -0.001 Tc 0.196 Tw [ (c) -4 (l) -0.6 (o) -1.8 (s) -4 (e) -1.9 (\040p) -1.9 (r) -3.3 (o) -1.9 (x) 2 (i) -0.6 (mi) -0.6 (t) 1.6 (y) ] TJ 0 Tc 0 Tw 16.701 0 Td (\040) Tj 0.001 Tc 0.194 Tw 0.473 0 Td [ (o) -5.9 (f) 3.6 (\040t) 3.6 (he\040hy) 4 (dr) -1.3 (ox) 4 (y) -2 (m) 1.7 (et) 3.6 (hy) 4 (l) 1.5 (at) 3.6 (ed\040c) 3.9 (y) 4 (t) 3.6 (os) -2 (i) 1.5 (ne) 6.1 (s) -2 (\040\050) -1.3 (S) 3.3 (r) 4.7 (ando) 6.2 (ur) -1.3 (\040) ] TJ /TT3 1 Tf [ (et) 3.6 (\040al) ] TJ /TT1 1 Tf 24.228 0 Td [ (\056) 3.6 (\054) 3.5 (\0402016\051) -1.4 (\056) 9.6 (\040) ] TJ ET 1 g 70.92 238.08 453.48 11.52 re f* BT 0 g -0.001 Tw 10.02 0 0 10.02 70.92 240.3 Tm [ (A) 3.3 (ppr) -1.3 (o) 6.1 (pr) -1.3 (i) 1.4 (at) ] TJ 4.611 0 Td (e\040) Tj -0.005 Tc 0.005 Tw 0.844 0 Td [ (bi) -4.6 (o) ] TJ 0.001 Tc -0.001 Tw 1.329 0 Td [ (i) 1.5 (nf) 3.5 (or) -1.3 (m) 7.7 (at) 3.6 (i) 1.4 (c) ] TJ 0 Tc 0 Tw 4.329 0 Td (\040) Tj -0.002 Tc 0.002 Tw 0.287 0 Td [ (t) 0.6 (r) ] TJ 0.001 Tc 0.009 Tw 0.611 0 Td [ (eat) 3.6 (m) 1.7 (ent) 3.6 (\040) 0.6 (of) 3.5 (\040) 0.6 (t) 3.6 (h) -5.9 (e\040) 0.6 (s) -2 (equ) 6.1 (en) 6.1 (c) -2 (i) 1.5 (ng) 6.1 (\040) 0.6 (r) -1.3 (eads) ] TJ 0 Tc 0 Tw 14.605 0 Td (\040) Tj 0.001 Tc 0.009 Tw 0.287 0 Td [ (t) 3.6 (hen\040) 0.6 (a) 6.1 (s) -2 (s) -2 (i) 7.5 (gn) ] TJ 0 Tc 0 Tw 5.114 0 Td (s) Tj 0.503 0 Td (\040) Tj 0.001 Tc -0.001 Tw 0.287 0 Td [ (hy) 4 (dr) ] TJ 1.946 0 Td [ (ox) 10 (y) 4 (m) 1.7 (et) 3.6 (hy) 4 (l) 1.4 (at) 3.6 (i) 1.5 (on) ] TJ 0 Tc 0 Tw (\040) Tj 0.001 Tc 0.009 Tw 6.94 0 Td [ (s) -2 (c) 4 (or) -1.3 (e\040) 0.6 (t) 3.6 (o) 6.1 (\040) ] TJ ET 1 g 70.92 220.86 86.7 11.52 re f* BT 0 g -0.009 Tw 10.02 0 0 10.02 70.92 223.08 Tm [ (t) 3.6 (he\040) -5.4 (c) -2 (apt) 3.6 (u) 6.1 (r) -1.3 (ed\040) 0.5 (C) -1.5 (pG) 6.6 (s) -2 (\056) ] TJ /TT2 1 Tf 0 Tc 0 Tw 8.653 0 Td (\040) Tj ET EMC BT /P << /MCID 14 >> BDC 10.02 0 0 10.02 70.92 205.74 Tm (\040) Tj EMC ET /P << /MCID 15 >> BDC BT 0.001 Tc -0.003 Tw 10.02 0 0 10.02 70.92 188.52 Tm [ (M) 1.7 (at) -1.3 (er) 0.8 (i) 3.5 (al) 3.5 (s\040) 0.6 (a) 6.1 (n) 7.2 (d) 1.2 (\040) 0.6 (R) -1.6 (eag) 7.2 (en) 1.3 (t) 4.6 (s) ] TJ 0 Tc 0 Tw 11.144 0 Td (\040) Tj ET 70.92 186.36 111.66 1.08 re f* EMC BT /P << /MCID 16 >> BDC 10.02 0 0 10.02 70.92 171.24 Tm (\040) Tj EMC /LBody << /MCID 19 >> BDC /TT1 1 Tf 0.001 Tc -0.001 Tw 1.778 -1.713 Td (1\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.001 Tc -0.009 Tw 0.952 0 Td [ (P) 3.3 (i) 1.5 (pet) 3.6 (t) 3.5 (e\040) 0.5 (t) 3.6 (i) 1.4 (ps) -2 (\040) 6.6 (\050) -1.4 (T) 43.2 (i) 1.5 (pO) 0.5 (ne\054) 3.5 (\040) 0.6 (S) 9.3 (T) 73.1 (A) 3.3 (R) 4.5 (LA) 3.3 (B) 3.4 (\054) 3.5 (\040) 0.6 (c) -2 (at) 3.6 (al) 1.4 (og) 6.1 (\040) 6.5 (num) 1.7 (be) 6.1 (r) 4.7 (s) -2 (\072) 3.6 (\040) ] TJ -0.001 Tw 22.246 0 Td [ (S) 3.3 (1) 78 (161) ] TJ 0 Tc 0 Tw (\055) Tj 0.001 Tc -0.001 Tw 3.144 0 Td [ (180) 6.1 (0) ] TJ -0.002 Tc 0.002 Tw [ (\054) 0.5 (\040) ] TJ 0.001 Tc -0.001 Tw 2.766 0 Td [ (S) 3.3 (1) 78 (182) ] TJ 0 Tc 0 Tw (\055) Tj 0.001 Tc -0.001 Tw 3.144 0 Td [ (183) 6.1 (0) ] TJ -0.009 Tw [ (\054) 3.5 (\040) 0.6 (an) 6.1 (d\040) ] TJ -0.071 Tc 0.071 Tw 4.701 0 Td [ (S) -68.7 (11) -65.9 (8) -71.9 (1) ] TJ 0 Tc 0 Tw 2.814 0 Td (\055) Tj 0.001 Tc -0.001 Tw 0.329 0 Td [ (381) 6.1 (0) ] TJ 0 Tc 0 Tw (\051) Tj 2.551 0 Td (\040) Tj EMC /LBody << /MCID 23 >> BDC 0.001 Tc -0.001 Tw -43.479 -1.719 Td (2\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.001 Tc -0.003 Tw 0.952 0 Td [ (0\056) 3.6 (65\040) 0.6 (m) 1.6 (l) 1.5 (\040) 0.5 (B) 3.4 (i) 1.4 (or) -1.4 (u) 6.1 (pt) 3.5 (or) -1.3 (\040) 0.6 (m) 1.6 (i) 1.5 (c) 4 (r) -1.3 (ot) 3.5 (ub) 6.1 (es) -2 (\040) 0.6 (\050) 4.6 (D) -1.5 (i) 1.4 (ag) 6.2 (eno) 6.1 (d) 6.1 (e\054) 3.6 (\040) 0.6 (c) -2 (at) 3.5 (al) 1.4 (og\040) 0.5 (n) 6.1 (u) 6.1 (m) 1.7 (ber) -1.3 (\072) 3.6 (\040) ] TJ -0.001 Tw 26.186 0 Td [ (C) 4.4 (300) 6.1 (1) 6.1 (001) 78 (1) ] TJ 0 Tc 0 Tw (\051) Tj 5.413 0 Td (\040) Tj EMC /LBody << /MCID 27 >> BDC 0.001 Tc -0.001 Tw -33.383 -1.725 Td (3\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.001 Tc -0.045 Tw 0.952 0 Td [ (0\056) 3.6 (5\040) 0.5 (m) 1.6 (l) 1.5 (\040) 0.5 (an) 6.1 (d\040) 0.5 (2\040) 6.5 (m) 1.6 (l) 1.5 (\040) 0.5 (D) 4.4 (N) -1.5 (A) 57.2 (\040) 0.5 (LoB) 3.4 (i) 7.4 (n) 6.1 (d\040) 0.5 (t) 3.6 (ube) 6.1 (s) -2 (\040) 0.5 (\050) -1.3 (E) 9.3 (ppe) 6.2 (ndor) -1.3 (f) 3.6 (\054) 3.5 (\040) ] TJ 20.623 0 Td [ (c) -2 (at) 3.6 (al) 1.5 (o) 6.1 (g) 6.1 (\040) 0.5 (num) 1.7 (b) 6.1 (er) 4.7 (s) -2 (\072) ] TJ 0 Tc 0 Tw 7.611 0 Td (\040) Tj 0.001 Tc -0.001 Tw 0.234 0 Td [ (00) 6.1 (3010) 6.1 (8035) ] TJ 0 Tc 0 Tw 5.551 0 Td (\040) Tj 0.001 Tc -0.001 Tw 0.234 0 Td [ (an) 6.1 (d\040) ] TJ 1.898 0 Td [ (003) 6.1 (010) 6.1 (807) 6.1 (8) ] TJ 0 Tc 0 Tw 5.545 0 Td (\051) Tj 0.329 0 Td (\040) Tj EMC /LBody << /MCID 31 >> BDC 0.001 Tc -0.001 Tw -43.808 -1.719 Td (4\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj -0.001 Tc -0.001 Tw 0.952 0 Td [ (Mi) -0.6 (c) -4 (r) 2.7 (o) -1.9 (\040) 0.5 (B) 1.3 (i) -0.6 (o) ] TJ 0 Tc 0 Tw 4.162 0 Td (\055) Tj 0.335 0 Td (S) Tj 0.001 Tc -0.003 Tw 0.665 0 Td [ (pi) 7.4 (n\040) 0.5 (6\040) 0.5 (c) -2 (ol) 1.5 (um) 7.7 (n\040) 0.5 (\050) 4.7 (B) 3.3 (i) 1.5 (o) ] TJ 0 Tc 0 Tw (\055) Tj 0.001 Tc -0.003 Tw 8.042 0 Td [ (R) 4.5 (ad\040) 0.5 (La) ] TJ 3.216 0 Td [ (bo) 6.1 (r) -1.3 (at) 3.6 (or) -1.3 (i) 7.4 (es) -1.9 (\054) 3.5 (\040) 0.6 (c) 4 (at) 3.6 (al) 7.4 (og\040) 0.6 (num) 1.7 (b) 6.1 (er) -1.4 (\072) 3.6 (\040) ] TJ -0.005 Tc 0.005 Tw 12.425 0 Td [ (73) -5.9 (2) ] TJ 0.001 Tc -0.001 Tw 1.665 0 Td [ (62) 6.1 (21) ] TJ 0 Tc 0 Tw (\051) Tj 2.551 0 Td (\040) Tj EMC /LBody << /MCID 35 >> BDC 0.001 Tc -0.001 Tw -34.844 -1.725 Td (5\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.001 Tc -0.003 Tw 0.952 0 Td [ (1\056) 3.6 (5\040) 0.5 (m) 1.7 (l) 1.5 (\040) 0.5 (Lobi) 1.5 (nd) 6.1 (\040) 0.5 (t) 3.6 (ube) ] TJ 0 Tc 0 Tw (s) Tj 8.719 0 Td (\040) Tj 0.001 Tc -0.003 Tw 0.275 0 Td [ (\050) -1.3 (E) 3.3 (p) 6.1 (pe) 6.1 (ndor) -1.3 (f) 3.5 (\054) 3.6 (\040) 0.6 (c) 4 (at) 3.5 (al) 1.4 (og) 6.1 (\040) 0.6 (num) 1.7 (be) 6.1 (r) -1.3 (\072) 3.6 (\040) ] TJ -0.001 Tw 12.922 0 Td [ (003) 6.1 (0108) 6.1 (051) ] TJ 0 Tc 0 Tw 5.551 0 Td (\051) Tj 0.329 0 Td (\040) Tj EMC ET Q q 1 0 0 1 0 0 cm BT /F1 12 Tf 14.4 TL ET 0.1 w 0.5 0.5 0.5 RG n 72 813.6 452.88 21.6 re S q 1 0 0 1 0 817 cm q BT 1 0 0 1 75 9.5 Tm 8 TL /F2 6.5 Tf 0 0 0 rg (Please\040cite\040this\040article\040as\072) Tj /F1 6.5 Tf (\040Aurlien\040) Tj /F3 6.5 Tf (et\056\040al\056) Tj /F1 6.5 Tf (\054\040\0502018\051\056\040Coupling\040Exonuclease\040Digestion\040with\040Selective\040Chemical\040Labeling\040for\040Base\055resolution\040Mapping\040of) Tj T* (5\055Hydroxymethylcytosine\040in\040Genomic\040DNA\054\040) Tj /F3 6.5 Tf (Bio\055protocol) Tj /F1 6.5 Tf (\0408\040\0505\051\072\040e2747\056\040DOI\072\04010\05621769\057BioProtoc\0562747\056) Tj T* ET Q Q Q endstream endobj 25 0 obj << /CS /DeviceRGB /S /Transparency >> endobj 26 0 obj << /AIS false /BM /Normal /CA 1 /OP false /OPM 1 /SA true /SMask /None /Type /ExtGState /ca 1 /op false >> endobj 27 0 obj << /BaseFont /LMCIPR+Cambria /Encoding /WinAnsiEncoding /FirstChar 32 /FontDescriptor 28 0 R /LastChar 32 /Subtype /TrueType /ToUnicode 30 0 R /Type /Font /Widths [ 220 ] >> endobj 28 0 obj << /Ascent 3117 /CapHeight 667 /Descent -2464 /Flags 34 /FontBBox [ -1475 -2464 2868 3117 ] /FontFamily (Cambria) /FontFile2 29 0 R /FontName /LMCIPR+Cambria /FontStretch /Normal /FontWeight 400 /ItalicAngle 0 /StemV 84 /Type /FontDescriptor /XHeight 467 >> endobj 29 0 obj << /Filter /FlateDecode /Length1 78708 /Length 27612 >> stream HԖw\UGsby9D
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